Research
Introduction
Post-transcriptional regulation is an important layer for gene expression regulation.
Fluorescence Reporters for Splicing Codes
By constructing multi-chromatic alternative splicing reporter mini-genes for a nematode C. elegans, we successfully visualized cell-type-specific and developmentally regulated alternative splicing events in vivo.
Alternative Splicing Coupled with NMD
Alternative splicing of pre-mRNAs can regulate gene expression levels by coupling with nonsense-mediated mRNA decay.
m6A-Mediated Alternative Splicing for Homeostasis
Alternative splicing coupled with nonsense-mediated mRNA decay (NMD) regulates metabolic enzyme genes.
RNA-Binding Protein in DCM
Dilated cardiomyopathy (DCM) is a disease in which the heart becomes enlarged and no longer pumps blood effectively.
DCM Model Animals
We generated an Rbm20(S637A) knock-in mouse, mimicking an un-phosphorylatable mutation found in a well-studied case of DCM as well as an Rbm20 knock-out mouse.
Cellular Splicing Codes
このページでは、mRNA前駆体のスプライシングについて概略を説明しています。
