University of the Ryukyus Grad Sch Medicine Department of Biochemistry KUROYANAGI Laboratory

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University of the Ryukyus Grad Sch Medicine
Department of Biochemistry KUROYANAGI Laboratory

Welcome to Department of Biochemistry!

We have developed a fluorescence reporter system to visualize alternative pre-mRNA splicing events in vivo and are studying the regulation mechanisms, or so called "splicing codes". We are also studying disease models caused by disregulation of gene expression.

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News

2023.12.11
Presentation
Prof. KUROYANAGI presents our work in a symposium held at Kyoto University.
2023.12.10
Outreach
Prof. KUROYANAGI gives a lecture in the RYUDAI Science School.
2023.11.27
Promotion
Two undergrad students join the lab for Medical Science Research.
2023.11.17
Presentation
Prof. KUROYANAGI gives a talk at IECB in Bordeaux, France.
2023.11.13
Presentation
Prof. KUROYANAGI presents our work in the RBM20-DCM Meeting at EMBL Heidelberg.
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Hello Everyone!

I am KUROYANAGI Hidehito, a new professor of the Department of Biochemistry. I am very much pleased to join University of the Ryukyus Graduate School of Medicine.
I have been studying regulation mechanisms of gene expression in animals, especially of alternative pre-mRNA processing in living organisms. I have developed a new method to visualized pre-mRNA processing patterns in living cells or organisms and applied the system to tissue-specific and/or developmentally regulated alternative splicing events. We are also studying animal models of diseases caused by missense mutations in regulators of pre-mRNA processing or mRNA translation.

I am looking forward to studying these subjects with highly motivated undergrad and graduate students in Okinawa.

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Research

Introduction
Post-transcriptional regulation is an important layer for gene expression regulation.
Fluorescence Reporters for Splicing Codes
By constructing multi-chromatic alternative splicing reporter mini-genes for a nematode C. elegans, we successfully visualized cell-type-specific and developmentally regulated alternative splicing events in vivo.
Alternative Splicing Coupled with NMD
Alternative splicing of pre-mRNAs can regulate gene expression levels by coupling with nonsense-mediated mRNA decay.
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