研究業績

原著

2020年

Sayomi Higa-Nakamine, Shiho Okitsu-Sakurayama, Shinichiro Kina, and Hideyuki Yamamoto
Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor.
The FEBS Journal. in press

Izumi Nakayama, Sayomi Higa-Nakamine, Ayako Uehara, Kazuhiro Sugahara, Manabu Kakinohana, Hideyuki Yamamoto
Regulation of Epidermal Growth Factor Receptor Expression and Morphology of Lung Epithelial Cells by Interleukin-1β.
The Journal of Biochemistry. in press

Kaoru Arakaki, Ayako Uehara, Sayomi Higa-Nakamine, Manabu Kakinohana, Hideyuki Yamamoto
Increased expression of EGR1 and KLF4 by polysulfide via activation of the ERK1/2 and ERK5 pathways in cultured intestinal epithelial cells
Biomedical Research. In press

2019年

Okitsu-Sakurayama S, Higa-Nakamine S, Torihara H, Takahashi H, Higashiyama S, Yamamoto H.
Activation of Pyk2 by CaM kinase II in cultured hypothalamic neurons and gonadotroph cells. J Cell Physiol. 2019 May;234(5):6865-6875. doi: 10.1002/jcp.27443.

2018年

Higa T, Takahashi H, Higa-Nakamine S, Suzuki M, Yamamoto H.
Up-regulation of DUSP5 and DUSP6 by gonadotropin-releasing hormone in cultured hypothalamic neurons, GT1-7 cells. Biomed Res. 2018;39(3):149-158. doi: 10.2220/biomedres.39.149.

Shunsuke Izumi, Sayomi Higa-Nakamine, Hiroyuki Nishi, Hidetsugu Torihara, Ayako Uehara, Kazuhiro Sugahara, Manabu Kakinohana, Hideyuki Yamamoto
Phosphorylation of epidermal growth factor receptor at serine 1047 in cultured lung alveolar epithelial cells by bradykinin B2 receptor stimulation. Pulm Pharmacol Ther. 2018 Feb;48:53-61.

2017年

Omoto Y, Higa-Nakamine S, Higa A, Yamamoto H.
ErbB4 cleavage by gonadotropin-releasing hormone receptor stimulation in cultured gonadotroph cells. Eur J Pharmacol. 15 (799): 171-179 2017

Sugaya K, Nishijima S, Kadekawa K, Ashitomi K, Ueda T, Yamamoto H, Hattori T.
Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats. Neurourol Urodyn 36: 604-609, 2017.doi:10.1002/nau.23028.

Sugaya K, Nishijima S, Kadekawa K, Ashitomi K, Ueda T, Yamamoto H.
Naftopidil Improves Symptoms in a Rat Model of Tranilast-Induced Interstitial Cystitis. Low Urin Tract Symptoms 9: 107-110, 2017.doi:10.1111/luts.12113.

2016年

Kondo, S. Higa-Nakamine, N. Maeda, S. Toku, M. Kakinohana, K. Sugahara, I. Kukita & H. Yamamoto.
Stimulation of cell migration by flagellin through the p38 MAP kinase pathway in cultured intestinal epithelial cells. J. Cell. Biochem. 117(1): 247-258 2016

2015年

Higa-Nakamine S, Maeda N, Toku S, Yamamoto H.
Involvement of Protein Kinase D1 in Signal Transduction from the Protein Kinase C Pathway to the Tyrosine Kinase Pathway in Response to Gonadotropin-Releasing Hormone. J Biol Chem. 290 (43): 25974-25985 2015

H. Nishi, N. Maeda, S. Izumi, S. Higa-Nakamine, S. Toku, M. Kakinohana, K. Sugahara & H. Yamamoto.
Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells. Eur. J. Pharmacol. 748: 133-142 2015

2014年

Sugaya K, Nishijima S, Kadekawa K, Ashitomi K, Ueda T & Yamamoto H.
Spinal mechanism of micturition reflex inhibition by naftopidil in rats. Life Sci 116: 106-111,2014.

Yamamoto H, Higa-Nakamine S, Noguchi N, Maeda N, Kondo Y, Toku S, Kukita I & Sugahara K.
Desensitization by different strategies of epidermal growth factor receptor and ErbB4. J Pharmacol Sci 124: 287-293, 2014.

Sugaya K, Nishijima S, Kadekawa K, Ashitomi K, Ueda T & Yamamoto H.
Intravenous or local injections of flavoxate in the rostral pontine reticular formation inhibit urinary frequency induced by activation of medial frontal lobe neurons in rats. J Urol 192: 1278-1285, 2014.

2013年

Nishijima, K. Sugaya, K. Kadekawa, K. Ashitomi, T. Ueda & H. Yamamoto.
High-dose transit administration to rats creates interstitial cystitis-like symptoms with increased vascular permeability. Life Sci. 93: 897-903 2013

K. Kadekawa, K. Sugaya, S. Nishijima, K. Ashitomi, M. Miyazato, T. Ueda & H. Yamamoto.
Effect of naftopidil, an alpha1D/A-adrenoceptor antagonist, on the urinary bladder in rats with spinal cord injury. Life Sci. 92: 1024-1028 2013

N. Noguchi, Y. Kondo, N. Maeda, S. Higa-Nakamine, S. Toku, J. Maruyama, Y. Isohama, I. Kukita, K. Sugahara & H. Yamamoto.
Phosphorylation of epidermal growth factor receptor at serine 1047 by MAP kinase-activated protein kinase-2 in cultured lung epithelial cells treated with flagellin. Arch. Biochem. Biophys . 529: 75-85 2013

山本秀幸, 近藤豊, 野口信弘, 仲嶺三代美, 前田紀子, 徳誠吉, 礒濱洋一郎, 久木田一郎, 須加原一博
レジオネラ肺感染症におけるフラジェリンのⅡ型肺胞上皮細胞に対する影響. 日本肺サーファクタント•界面医学会雑誌 44: 57-58, 2013.

山本秀幸, 仲嶺三代美:
視床下部神経細胞でのGnRH受容体刺激によるErbB4の切断反応. 生体の科学 64: 468-469, 2013.

2012年

S. Higa-Nakamine, N. Maeda, S. Toku, T. Yamamoto, M. Yingyuenyong, M. Kawahara & H. Yamamoto.
Selective cleavage of ErbB4 by G-protein-coupled gonadotropin-releasing hormone receptor in cultured hypothalamic neurons. J. Cell. Physiol . 227: 2492-2501 2012

S. Higa-Nakamine, T. Suzuki, T. Uechi, A. Ghakraborty, Y. Nakajima, M. Nakamura, N. Hirano, T. Suzuki, N. Kenmochi.
Loss of ribosomal RNA modification causes developmental defects in zebrafish. Nucleic Acids Res, 40(1): 391-398. 2012

S. Nishijima, K. Kadekawa, K. Ashitomi, H. Yamamoto , & K. Sugaya.
Effect of chemical stimulation of the medial frontal lobe on the micturition reflex in rats. J. Urol . 187: 116-1120 2012

S. Nishijima, K. Sugaya, K. Kadekawa, K. Ashitomi, & H. Yamamoto.
Synergistic effect by co-administration of tamusulosin and solifenacin on bladder activity in rats. LUTS (lower urinary tract symptoms) , 4 (1): 3-8 2012

K. Sugaya, S. Nishijima, K. Kadekawa, K. Ashitomi, & H. Yamamoto.
Effect of distigmine combined with propiverine on bladder activity in rats with spinal cord injury. Int. J. Urol . 19: 480-483 2012

S. Taniguchi, T. Kimura, T. Umeki, Y. Kimura, H. Kimura, I. Ishii, N. Itoh, Y. Naito, H. Yamamoto , & I. Niki.
Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine g -lyase in the pancreatic β-cell. Mol. Cell. Endocrinol. 350: 31-38 2012

K. Kadekawa, S. Nishijima, K. Ashitomi, H. Yamamoto , & K. Sugaya.
Excitatory effect of propiverine hydrochloride on urethral activity in rats. Int. J. Urol . 19: 575-582 2012

Y. Kondo, S. Higa-Nakamine, N. Noguchi, N. Maeda, S. Toku, Y. Isohama, K. Sugahara, I. Kukita & H. Yamamoto.
Induction of epithelial-mesenchymal transition by flagellin in cultured lung epithelial cells. Am. J. Physiol . -Lung Cell. Mol. 303: L1057-L1069 2012

2011年

S. Nishijima, K. Sugaya, K. Kadekawa, K. Ashitomi, & H. Yamamoto.
Efficacy of propiverine, an anticholinergic agent, in young and old rats. Life Sci . 89: 456-459 2011

A. Mizutani, N. Maeda, S. Toku, S. Higa-Nakamine, Y. Isohama, H. Sunakawa, K. Sugahara, H. Yamamoto.
Interaction of ethyl pyruvate in vitro with NF- κ B subunits, RelA and p50. Eur J Pharmacol 2011;650:151-156.

2010年

A. Mizutani, N. Maeda, S. Toku, Y. Isohama, K. Sugahara, H. Yamamoto.
Inhibition by ethyl pyruvate of the nuclear translocation of nuclear factor-κB in cultured lung epithelial cells. Pulm. Pharmacol. Ther. 23:308-315 2010

2009年

N. Maeda, S. Toku, Y. Naito, H. Nishiura, T. Tanaka & H. Yamamoto.
Phosphorylation of Ribosomal Protein S19 at Ser59 by CaM Kinase Iα. J. Neurochem. 109: 393-402 2009

Q.S. Hossain, E. Ulziikhishig, K.W. Lee, H. Yamamoto & Y. Aniya
Contribution of liver mitochondrial membrane-bound glutathione transferase to mitochondrial permeability transition pores. Toxicol. Appl. Pharmacol. 235:77-85 2009

S. Mutiara, H. Kanasaki, A. Oride, I.N. Purwana, S. Shimasaki, H. Yamamoto & K. Miyazaki
Follistatin gene expression by gonadotropin-releasing hormone: a role for cyclic AMP and mitogen-activated protein kinase signaling pathways in clonal gonadotroph Lbeta T2 cells. Mol. Cell. Endocrinol. 13:125-132 2009

2008年

T. Song, N. Hatano, T. Kambe, Y. Miyamoto, H. Ihara, H. Yamamoto , K. Sugimoto, K. Kume, F. Yamaguchi, M. Tokuda & Y. Watanabe
Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II. Biochem. J. 412: 223-231 2008

2007年

A. Yamanaka, Y. Hiragami, N. Maeda, S. Toku, M. Kawahara, Y. Naito, & H. Yamamoto
Involvement of CaM kinase II in gonadotropin-releasing hormone-induced activation of MAP kinase in cultured hypothalamic neurons. Arch. Biochem. Biophys. 466: 234-241 2007

A. Uezu, A. Horiuchi, K. Kanda, N. Kikuchi, K. Umeda, K. Tsujita, S. Suetsugu, N. Araki, H. Yamamoto , T. Takenawa, & H. Nakanishi
SGIP1α is an endocytic protein that directly interacts with phospholipids and Eps15 . J. Biol. Chem. 282: 26481-26489 2007

2006年

N. Maeda, S. Toku, N. Kenmochi, T. Tanaka
A novel nucleola protein interacts with ribosomal protein S19. Biochem. Biophys. Res. Commun., 339: 41-16 2006

M. Morioka, T. Kawano, S. Yano, Y. Kai, H. Tsuiki, Y. Yoshinaga, J. Matsumoto, T. Maeda, J. Hamada, H. Yamamoto , K. Fukunaga, & J. Kuratsu
Hyperphosphorylation at serine 199/202 of tau factor in the gerbil hippocampus after transient forebrain ischemia. Biochem. Biophys. Res. Commun., 347: 273-278 2006

T. Seki, N. Irie, K. Nakamura, H. Sakaue, W. Ogawa, M. Kasuga, H. Yamamoto , S. Ohmori, N. Saito, & N. Sakai
Fused protein of δPKC activation loop and PDK1-interacting fragment (δAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells. Genes to Cells, 11: 1051-1070 2006

2005年

H. Yamamoto , Y. Hiragami, M. Murayama, K. Ishizuka, M. Kawahara & A. Takashima
Phosphorylation of tau at serine 416 by Ca 2+ /calmodulin-dependent protein kinase II in neuronal soma in brain. J. Neurochem., 94: 1438-1447 2005

Y. Nagayoshi, T. Ohba, H. Yamamoto , Y. Miyahara, H. Tashiro & H. Okamura
Characterization of 17β-hydroxysteroid dehydrogenase type 4 in human ovarian surface epithelial cells. Mol. Hum. Reprod. 11: 615-621 2005

2004年

Y. Yamada, H. Yamamoto , T. Yonehara, H. Kanasaki, H. Nakanishi, E. Miyamoto & K. Miyazaki
Differential activation of the luteinizing hormoneβ-subunit promoter by activin and gonadotropin-releasing hormone. A role for the mitogen-activated protein kinase signaling pathway in LβT2 gonadotrophs. Biol. Reprod., 70: 236-243 2004

2003年

T. Nomura, H. Mimata, Y. Takeuchi, H. Yamamoto , E. Miyamoto & Y. Nomura
The X-linked inhibitor of apoptosis protein inhibits taxol-induced apoptosis in LNCaP cells. Urological Res., 31: 37-44 2003

H. Yamamoto , K. Matsumoto, E. Araki & E. Miyamoto
Involvement of Ca 2+ /calmodulin-dependent phosphorylation of synapsin I in insulin exocytosis. J. Pharmacol. Sci., 93: 30-34 2003

2002年

H. Yamamoto, E. Yamauchi, H. Taniguchi, T. Ono & E. Miyamoto
Phosphorylation of microtubule-associated protein tau by Ca2+ /calmodulin-dependent protein kinase II in its tubulin binding sites. Arch. Biochem. Biophys., 408: 255-262 2002

S. Toku, I. K.E. Quaye,& T. Tanaka
Isolation and characterization of chicken GA-binding protein. Biochim. Biophys. Acta., 1579: 50-54 2002

T. Uechi, N. Maeda, T. Tanaka & N. Kenmochi
Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes. Nucleic. Acids. Res.,30: 5369-5375 2002

S. Higa, N. Maeda, N. Kenmochi, & T. Tanaka
Location of 2′-o-methyl nucleotides in 26S rRNA and methylation guide snoRNAs in Caenorhadbitis elegans. Biochem. Biophys. Res. Commun., 297: 1344-1349 2002

2001年-2000年

T. Yonehara, H. Kanasaki, H. Yamamoto , K. Fukunaga, K. Miyazaki & E. Miyamoto
Involvement of mitogen-activated protein kinase in cyclic adenosine 3′, 5′-monophosphate-induced hormone gene expression in rat pituitary GH 3 cells. Endocrinology 142: 2811-2819 2001

N. Ogata, H. Yamamoto , K. Kugiyama, H. Yasue & E. Miyamoto
Involvement of protein kinase C in superoxide anion-induced activation of nuclear factor-κB in human endothelial cells. Cardiovasc. Res. 45:513-521 2000

Y. Takeuchi, H. Yamamoto , T. Miyakawa & E. Miyamoto
Increase of brain-derived neurotrophic factor gene expression in NG108-15 cells by the nuclear isoforms of Ca 2+ /calmodulin-dependent protein kinase II. J. Neurochem. 74:1913-1922 2000

Y. Takeuchi, H. Yamamoto , K. Fukunaga, T. Miyakawa & E. Miyamoto
Identificaion of the isoforms of Ca 2+ /calmodulin-dependent protein kinase II in rat astrocytes and their subcellular localization. J. Neurochem. 74:2557-2567 2000

H. Tabuchi, H. Yamamoto , K. Matsumoto, K. Ebihara, Y. Takeuchi, K. Fukunaga, H. Hiraoka, Y. Sasaki, M. Shichiri & E. Miyamoto
Regulation of insulin secretion by overexpression of Ca 2+ /calmodulin-dependent protein kinase II in insulinoma MIN6 cells. Endocrinology 141:2350-2360 2000

S. Ohmori, N. Sakai, Y. Shirai, H. Yamamoto , E. Miyamoto, N. Shimizu & N. Saito
Importance of protein kinase C targeting for the phosphorylation of its substrate, myristoylated alanine-rich C-kinase substrate. J. Biol. Chem. 275:26449-26457 2000

N. Inagaki, M. Nishizawa, N. Akimura, H. Yamamoto , Y. Takeuchi, E. Miyamoto, K. Kaibuchi & M. Inagaki
Activation of Ca 2+ /calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons. J. Biol. Chem. 275:27165-27171 2000

著書

山本秀幸

臨床症例 イラストレイテッド生化学[原書6版] 623-659 2015

山本秀幸

タンパク質リン酸化研究におけるアイソトープの活用 細胞工学 25:1198-1203 2006

山本秀幸

Ca 2+ /カルモジュリン依存性タンパク質リン酸化反応による細胞機能の制御  Ryukyu. Med. J., 25: 111-122 2006

山本秀幸

インスリンとカルシウムシグナルによるタウタンパク質リン酸化反応日

薬理誌 125:129-135 2005

山本秀幸

ELISA 、ウエスタンブロット 病理と臨床 22: 386-391 2004

山本秀幸

Ca 2+ /カルモジュリン依存性プロテインキナーゼ II の細胞内局在機構と生理機能 蛋白質・核酸・酵素 47: 241-247 2002

山本秀幸

タンパク質リン酸化研究におけるアイソトープの活用 細胞工学 25:1198-1203 2006

山本秀幸

Ca 2+ /カルモジュリン依存性タンパク質リン酸化反応による細胞機能の制御  Ryukyu. Med. J., 25: 111-122 2006

山本秀幸

インスリンとカルシウムシグナルによるタウタンパク質リン酸化反応日

薬理誌 125:129-135 2005

山本秀幸

ELISA 、ウエスタンブロット 病理と臨床 22: 386-391 2004

山本秀幸

Ca 2+ /カルモジュリン依存性プロテインキナーゼ II の細胞内局在機構と生理機能 蛋白質・核酸・酵素 47: 241-247 2002

特別講演

山本秀幸
神経細胞での G タンパク質共役型受容体刺激による EGF 受容体 – チロシンキナーゼ系の制御機構
熊本大学医学部保健学科検査技術学専攻セミナー、熊本 2.14, 2011

CaM キナーゼ I と CaM キナーゼ II による神経細胞機能の制御
北里大学薬学部大学院講義、ならびに学内公開セミナー、東京 6.26, 2009

山本秀幸
GnRH の産生と機能発現の制御機構
島根生殖医学セミナー、出雲 2.1, 2008

山本秀幸
カルシウム・カルモデュリン依存性タンパク質リン酸化反応による神経細胞機能の調節
産業医科大学大学院セミナー、北九州 5.2, 2008

山本秀幸
アルツハイマー病の病態生理への CaM キナーゼ II の関与
第 79 回日本薬理学会年会シンポジウム、横浜 3.8 〜 10, 2006

山本秀幸
アルツハイマー病での CaM キナーゼ II によるタウのリン酸化反応
第 33 回薬物活性シンポジウム、新潟 10.5, 2005

山本秀幸
タウの CaM キナーゼ II によるリン酸化反応のアルツハイマー病への関与
生理学研究所研究会「カルシウムシグナリング研究の新潮流」、岡崎 11.18 〜 19, 2004

山本秀幸 、宮本英七、中西宏之
インスリンとカルシウムシグナルによるタウ蛋白質燐酸化反応
第 77 回日本薬理学会年会シンポジウム、大阪 3.8 〜 10, 2004

山本秀幸 ,森岡基浩、生塩之敬、宮本英七
脳虚血後の神経細胞死へのカルシウム依存性蛋白質燐酸化反応の関与
第 76 回日本薬理学会年会、第 80 回日本生理学会大会合同学会シンポジウム 福岡  3.24 〜 26, 2003

山本秀幸 ,宮本英七
インスリン放出と Ca 2+ / カルモデュリン依存性のシナプシン I の燐酸化反応 第 75 回日本薬理学会年会シンポジウム 熊本  3.13 〜 15, 2002

山本秀幸 ,宮本英七
カルモデュリン依存性プロテインキナーゼ II の多様性とその生理的意義 大阪大学蛋白質研究所セミナー 「多機能性カルモデュリン依存性タンパク質リン酸化酵素 ― 活性化機構と機能 ―」 大阪  11.27 〜 28, 2001

国際学会

H. Yamamoto , 2007, Physiological and pathophysiological roles of CaM kinase II in neuronal functions., OIST-Korea workshop, “Neuroscience and beyond”, Onnna, Okinawa, Japan

H. Yamamoto , T. Kimura, J. Takamatsu, T. Miyakawa & E. Miyamoto, 2000, Phosphorylation of Myristoylated alanine-rich C kinase substrate in Alzheimer’s disease brains., International symposium on neuronal signaling and protein phosphorylation-dephosphorylation, Fukuoka, Japan

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